My research aims to understand how dietary nutrients are metabolized by host organs and gut microbiota and contribute to health and disease. I focus on disease-associated nutrients such as branched-chain amino acids, fructose and alcohol and study their metabolic fates and inter-organ exchange in diverse physiological and pathological conditions (diabetes and cancer). To achieve this goal, I use the state-of-the-art liquid chromatography mass spectrometry (LC-MS) and stable isotope tracing in disease animal models and human patients. My technical expertise and knowledge in mass spectrometry, metabolic flux analysis, analytical chemistry, and pathophysiology will expand our understanding of the fundamental link between diets, health and disease.